A Study to Evaluate the Safety and Efficacy of Intracranial Venous Blood Sampling for Liquid Biop… (NCT07467109) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
A Study to Evaluate the Safety and Efficacy of Intracranial Venous Blood Sampling for Liquid Biopsy in the Diagnosis of Brain Cancers
United States20 participantsStarted 2026-08-19
Plain-language summary
To learn if drawing blood directly from veins inside the brain is safe and can effectively provide the same kind of detailed information about high-grade glioma as traditional surgical biopsy.
Who can participate
Age range18 Years
SexALL
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Inclusion criteria
✓. For participants with known history of chronic hepatitis B virus (HBV) infection, the HBV viral load must be undetectable on suppressive therapy within 6 months, if indicated.
✓. Participants with a history of hepatitis C virus (HCV) infection must have been treated and cured. For participants with HCV infection who are currently on treatment, they are eligible if they have an undetectable HCV viral load within 6 months.
✓. Participants with a known history of human immunodeficiency virus (HIV on effective antiretroviral therapy with undetectable viral load within 6 months are eligible for this trial.
✓. Karnofsky Performance Scale ≥ 60%
✓. Participants must have adequate organ and marrow function as defined below:
Exclusion criteria
✕. Subjects with suspected glioma or other brain cancers who do not have a tissue diagnosis and no surgical biopsy or resection is anticipated.
✕. Subjects in whom diagnostic cerebral angiogram is contra-indicated defined as:
✕. For participants undergoing surgery, refractory coagulopathy or thrombocytopenia which cannot be corrected defined as:
✕. Subjects that have a known high risk in monitored anesthetic care or general anesthesia assessed by the treating physician.
✕. Anatomic considerations: based on cross-sectional imaging such as CT angiogram of the head and neck, the anatomy for arterial and venous vascular access is deemed unsuitable for endovascular access such as high-grade carotid artery stenosis, absent or occluded internal jugular veins, sigmoid sinuses and/or transverse sinuses.
What they're measuring
1
safety and adverse events (AEs).
Timeframe: Through study completion; an average of 1 year