RecruitingNot Applicable

Minimally-Invasive Non-Surgical Therapy of Peri-Implantitis

Czechia106 participantsStarted 2026-01-01

Plain-language summary

This multicenter, single-masked randomized controlled clinical trial evaluates the effectiveness of minimally-invasive non-surgical therapy (MINST) compared with standard non-surgical peri-implant therapy (NSPT) in patients diagnosed with peri-implantitis. The study investigates clinical outcomes, radiographic bone levels, patient-reported outcomes, and treatment time over 12 months.

Who can participate

Age range18 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Age ≥18 * Peri-implantitis diagnosis (PPD \>6 mm, BOP+, bone loss ≥3 mm) * Accessible implant surface without removing suprastructure * FMPS \<30%, FMBS \<30-35% Exclusion Criteria: * Antibiotics in last 3 months * Pregnancy/lactation * Uncontrolled diabetes (HbA1c ≥7) * Long-term SPIC (\>2 years) * Previous implant therapy \<12 months * Smoking/vaping in last 12 months * Hopeless implant * Need for adjunctive antibiotics

What they're measuring

Pocket closure at test site (implant site) - defined as PPD ≤5 mm, ≤1 bleeding point, no suppuration

Timeframe: Baseline, 3 months, 6 months, 9 months, 12 months.

Trial details

NCT IDNCT07466966

SponsorSt. Anne's University Hospital Brno, Czech Republic

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2028-01

Contact for this trial

MDDr. Filip Hromčík, Ph.D., MDDr., Ph.D.

+420 607987134 filiphromcik@mail.muni.cz

View on ClinicalTrials.gov More Peri-implantitis trials