Impact of Supplementation With Synbiotics and Prebiotics on Cognitive Decline Associated With Neoadjuvant Chemotherapy in First-line Patients With Breast Cancer

Inclusion Criteria: * Age: Participants must be between 18 and 75 years old. * Diagnosis: Must have a confirmed diagnosis of breast cancer at stages IB to IIIC. * Treatment Status: Participants should be scheduled to receive neoadjuvant chemotherapy as part of their treatment plan. * Cognitive Function: Must demonstrate baseline cognitive function as assessed by the CERAD neuropsychological battery, indicating no severe cognitive impairment. * Informed Consent: Participants must provide written informed consent to participate in the study and comply with all study procedures. * Health Status: Should not have any significant comorbidities that could interfere with the study outcomes, such as severe psychiatric disorders or neurological conditions. * No Previous Probiotic Use: Must not have used probiotics or prebiotics in the month prior to the study Exclusion Criteria: * Severe Cognitive Impairment: Participants with significant cognitive impairment or dementia as assessed by the CERAD neuropsychological battery will be excluded. * Severe Comorbidities: Participants with serious comorbid conditions, such as uncontrolled diabetes, severe cardiovascular diseases, or active infections, will be excluded. * Psychiatric Disorders: Individuals with a history of severe psychiatric disorders that could affect cognitive function or compliance with the study protocol will be excluded. * Neurological Conditions: Participants with neurological disorders such as multiple sclerosis, Park…