A Study to Evaluate ALN-4324 on Insulin Sensitivity in Adults With Type 2 Diabetes Mellitus (NCT07465224) | Clinical Trial Compass
RecruitingPhase 2
A Study to Evaluate ALN-4324 on Insulin Sensitivity in Adults With Type 2 Diabetes Mellitus
United States40 participantsStarted 2026-01-15
Plain-language summary
The purpose of this study is to evaluate the effect of a single dose of ALN-4324 on whole-body insulin sensitivity in participants with T2DM
Who can participate
Age range
18 Years – 65 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Is an adult patient with a confirmed diagnosis of T2DM
* Has a body mass index (BMI) of ≥25 kg/m\^2 and \<39.9 kg/m\^2
* Has a hemoglobin A1c (HbA1c) ≥6.5% to \<10.5%
* Is on a stable dose of metformin
Exclusion Criteria:
* Has any clinically significant concomitant disease, medical condition, or abnormal laboratory finding that could compromise participant safety or confound interpretation of study results
* Receiving therapies known to interfere with glucose or insulin metabolism other than current treatment for T2DM or birth control methods
Note: other protocol defined inclusion/exclusion criteria apply
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1This is a Phase 2 trial measuring something called the 'M-value' — can you explain what that measures in terms of insulin sensitivity, and what it would mean for my diabetes management if ALN-4324 shows a meaningful change in that number?
2Since this is still in Phase 2, the safety and effectiveness data on ALN-4324 are still being collected — given where I am in my Type 2 diabetes treatment journey, does it make more sense to try established medications first before considering an experimental study like this one?
3ALN-4324 appears to be a newer type of drug — can you tell me what kind of treatment it is, how it's given, and what side effects have been seen so far in earlier studies that I should weigh before deciding whether to look into this trial?
4The trial is actively recruiting right now — do you know what the eligibility requirements are, and are there aspects of my current health or medications that might make this trial a poor fit or even risky for me?
5If I were to join this trial, what would my regular treatment look like during the study — would I need to stop any of my current diabetes medications, and how would my blood sugar be managed if I end up in a placebo group?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.