A Trial Comparing Three Different Treatment Options for Adults With Low-Risk Myelodysplasia and Anemia (A MyeloMATCH Treatment Trial)

Inclusion Criteria: * Participants must have been registered to Master Screening and Re-Assessment Protocol (MYELOMATCH) prior to consenting to this study. Participants must have been assigned to this clinical trial, via MATCHBox Protocol Assignment Team, prior to registration to this study. Participants must have agreed to have specimens submitted for translational medicine and must be offered the opportunity to submit biosamples for banking for future research as per MYELOMATCH * Participants must have pathologically confirmed MDS according to World Health Organization (WHO) 2022 classification, without excess blasts * Lower risk MDS with a revised international prognostic scoring system (IPSS-R) score of less than or equal to 3.5 * Symptomatic anemia defined as either red blood cell (RBC) transfusion dependent, or hemoglobin \< 95 g/L with subjective fatigue or dyspnea * Age 18 years or greater * No prior therapy for myelodysplasia; including no luspatercept, imetelstat, emavusertib, lenalidomide, hypomethylating or immunosuppressive agents. Patients may have received up to 2 prior doses of erythropoietin stimulating agents (epoetin alfa or darbepoetin) if at least 8 weeks have elapsed between the prior therapy and study enrollment * No concurrent radiotherapy, biological, or any other investigational agents within 30 days prior to enrollment * Eastern Cooperative Oncology Group (ECOG) performance status 0, 1, or 2 * Absolute neutrophil count ≥ 0.5 x 10\^9/L * Platelet co…