Efficacy of Apixaban in the Treatment of Portal Vein Thrombosis Occurring More Than One Year Afte… (NCT07461545) | Clinical Trial Compass
RecruitingNot Applicable
Efficacy of Apixaban in the Treatment of Portal Vein Thrombosis Occurring More Than One Year After LS
China20 participantsStarted 2026-04-01
Plain-language summary
The purpose of this study is to determine whether Apixaban is effective and safe in the treatment of portal vein thrombosis Occurring more than one year after laparoscopic splenectomy.
Who can participate
Age range18 Years
SexALL
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Inclusion criteria
✓. A clinical, radiological, or histologic diagnosis of cirrhosis of any etiology.
✓. Splenomegaly with secondary hypersplenism.
✓. No evidence of portal vein thrombosis by ultrasound evaluation and angio-CT prior to surgery.
✓. Underwent laparoscopic splenectomy at our center.
✓. Orally received 2.5 mg of apixaban (CTTQ, Nanjing, China) twice daily or a 100 mg aspirin tablet (Bayer, Leverkusen, Germany) once daily for 6 months from POD 3.
✓. subcutaneous injections of low molecular weight heparin sodium (CSBio, Hebei, China) were administered for 5 days from POD 3
✓. Oral dipyridamole (Henan Furen, Henan, China) at a dosage of 25 mg, administered three times daily for 3 months from POD 3.
✓. Had no imaging evidence (Doppler ultrasound or CT) of portal vein thrombosis during postoperative months 6 to 12.
Exclusion criteria
✕. Hepatocellular carcinoma or any other malignancy.
✕. Hypercoagulable state other than the liver disease related.
✕. DRUGS- oral contraceptives, anticoagulation or anti-platelet drugs.
✕. Portal hypertension bleeding .
✕
What they're measuring
1
Proportion of complete recanalization of portal vein thrombosis