Clinical Evaluation of Simcyp-Guided Simvastatin Dosing in Patients With Liver Cirrhosis (NCT07459972) | Clinical Trial Compass
CompletedPhase 4
Clinical Evaluation of Simcyp-Guided Simvastatin Dosing in Patients With Liver Cirrhosis
Egypt22 participantsStarted 2024-03-15
Plain-language summary
This prospective open-label parallel pilot clinical study evaluated the efficacy and safety of physiologically based pharmacokinetic (PBPK)-guided simvastatin dosing in Child-Pugh A and B cirrhotic patients with portal hypertension over a 3-month period. Twenty-two patients were enrolled following screening, and portal hemodynamic, laboratory, and safety parameters were assessed.
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Adult patients aged ≥ 18 years
* Confirmed diagnosis of liver cirrhosis (clinical, laboratory, or imaging evidence)
* Evidence of portal hypertension (clinical findings and/or Doppler ultrasound measurements)
* No previous history of variceal bleeding
* Child-Pugh class A or B
Exclusion Criteria:
* Active hepatocellular carcinoma
* Severe renal impairment (eGFR \< 30 mL/min/1.73 m²)
* Baseline creatine kinase (CK) \> 3 × upper limit of normal
* Known hypersensitivity to simvastatin
* Current therapy with strong CYP3A4 inhibitors
* Any active malignancy in the last 2 years
* Pregnancy or lactation
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Change in Portal Vein Diameter (mm)
Timeframe: 3 months
2
Change in Portal Vein Velocity (cm/s)
Timeframe: 3 months
3
Change in Hepatic Artery Resistance Index (HARI)
Timeframe: 3 months
4
Change in Congestion Index (CI) (cm/ [cm/s2])
Timeframe: 3 months
5
Change in Modified Vascular Liver Index (MVLI) (cm/s)