Ingestion of food instigates the release of a battery of enteroendocrine peptide hormones that help control gut motility and digestive secretion. Peptide hormone products of the enteroendocrine L-cell and GLP-1 in particular, play multiple roles in relation to the regulation of pancreatic islet function and gastric emptying and the induction of satiety pathways in the central nervous system The mechanism of action of GLP-1 RAs on food intake reduction is mainly mediated through both peripheral and central nervous system (CNS) pathways. GLP-1 RAs directly stimulates POMC neurons and inhibits neuropeptide-Y (NPY) and Agouti-related peptide (AgRP) neurons in the arcuate nucleus resulting in a reduction in hunger and increases in fullness4. While there were studies which indirectly measured the changes of food preference and eating behaviour in humans after using GLP-1 RAs via visual analogue scales (VAS) or Patient's Experiences Questionnaires the investigators found there is a necessity to conduct the studies to do direct measurements of the changes of food preference and eating behaviour. Direct measures of an altered food selection in humans after using GLP-1 RAs have virtually not been performed likely due to the significant methodological and conceptual challenges they pose to researchers and study design. However, direct measures represent an essential component in the attempt to understand how GLP-1 RAs alters eating and diet selection which is the main reason of conducting this study. This innovative experiment will be a critical and a novel test of the explicit experience of humans with high-sugar high-fat fluids after using GLP-1 RAs and its potential role for the understanding of possible mechanisms determining post-treatment outcome such as weight loss.
Age range
18 Years – 75 Years
Sex
FEMALE
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
Energy Intake from Liquid Meal Consumption
Timeframe: At baseline, 4 weeks, 12 weeks, 24 weeks, 52 weeks
Macrostructure of Ingestive Behaviour (Rate of Energy Intake)
Timeframe: At baseline, 4 weeks, 12 weeks, 24 weeks, 52 weeks
Macrostructure of Ingestive Behaviour (Meal Duration)
Timeframe: At baseline, 4 weeks, 12 weeks, 24 weeks, 52 weeks
Macrostructure of Ingestive Behaviour (Number of Sucks)
Timeframe: At baseline, 4 weeks, 12 weeks, 24 weeks, 52 weeks
Microstructure of Ingestive Behaviour (Suck Energy Intake)
Timeframe: At baseline, 4 weeks, 12 weeks, 24 weeks, 52 weeks
Microstructure of Ingestive Behaviour (Suck Duration)
Timeframe: At baseline, 4 weeks, 12 weeks, 24 weeks, 52 weeks
Microstructure of Ingestive Behaviour (Suck Rate)
Timeframe: At baseline, 4 weeks, 12 weeks, 24 weeks, 52 weeks
Microstructure of Ingestive Behaviour (Suck Maximal Rate)
Timeframe: At baseline, 4 weeks, 12 weeks, 24 weeks, 52 weeks
Microstructure of Ingestive Behaviour (Burst Number)
Timeframe: At baseline, 4 weeks, 12 weeks, 24 weeks, 52 weeks
Microstructure of Ingestive Behaviour (Burst Duration)
Timeframe: At baseline, 4 weeks, 12 weeks, 24 weeks, 52 weeks
Microstructure of Ingestive Behaviour (Burst Energy Intake)
Timeframe: At baseline, 4 weeks, 12 weeks, 24 weeks, 52 weeks
Microstructure of Ingestive Behaviour (Burst Rate)
Timeframe: At baseline, 4 weeks, 12 weeks, 24 weeks, 52 weeks
Microstructure of Ingestive Behavior (Number of Sucks per Burst)
Timeframe: At baseline, 4 weeks, 12 weeks, 24 weeks, 52 weeks
Microstructure of Ingestive Behaviour (Inter-Burst Intervals)
Timeframe: At baseline, 4 weeks, 12 weeks, 24 weeks, 52 weeks
Microstructure of Ingestive Behaviour (Inter-Sucks Intervals)
Timeframe: At baseline, 4 weeks, 12 weeks, 24 weeks, 52 weeks