As the population ages, the growing prevalence of age-related diseases is creating substantial challenges for healthcare systems worldwide. Current therapeutic strategies often target individual diseases and decrease mortality without improving healthspan. The geroscience hypothesis suggests that targeting the ageing process itself could prevent, delay, or manage the severity of multiple age-related diseases concurrently, thereby improving overall healthspan and reducing healthcare burdens. Emerging research highlights several interconnected hallmarks of aging, such as mitochondrial dysfunction, chronic inflammation, impaired autophagy, and immune dysregulation, as modifiable through targeted interventions. Precision geromedicine represents a paradigm shift in addressing these processes, combining baseline diagnostics with individualized treatment strategies that adapt over time based on patient response. This approach integrates lifestyle modifications, dietary supplements, and pharmacological agents to optimize physical, cognitive, and immune function across the lifespan .
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Change from baseline in cardiorespiratory fitness (VOâ‚‚peak)
Timeframe: Baseline, Week 4, and Week 8
Change from baseline in muscle strength (one-repetition maximum (1RM))
Timeframe: Baseline, Week 4, and Week 8
Change from baseline in muscle mass (Ultrasound imaging)
Timeframe: Baseline, Week 4, and Week 8
Change from baseline in cognitive performance (NIH Toolbox Fluid Cognition Composite)
Timeframe: Baseline, Week 4, and Week 8
Change from baseline in immune function (CD4+: CD8+ ratio)
Timeframe: Baseline, Week 4, and Week 8