The Efficacy and Safety of Luspatercept in Improving Early Anemia After HSCT (NCT07450313) | Clinical Trial Compass
Not Yet RecruitingPhase 2
The Efficacy and Safety of Luspatercept in Improving Early Anemia After HSCT
20 participantsStarted 2026-03-14
Plain-language summary
This study aims to evaluate whether luspatercept can improve the efficacy and safety of anemia treatment in patients with hematologic malignancies after allogeneic hematopoietic stem cell transplantation.
Who can participate
Age range18 Years – 60 Years
SexALL
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Inclusion Criteria:
* 1\. Diagnosis of malignant hematological tumors and undergoing allogeneic hematopoietic stem cell transplantation.
* 2\. Expected survival after transplantation exceeds 1 month.
* 3\. Age 18-60 years.
* 4\. Hemoglobin ≤60 g/L on day 0 after transplantation.
* 5\. Eastern Cooperative Oncology Group (ECOG) score 0-2.
* 6\. Able to independently sign the informed consent form.
* 7\. The informed consent form must be signed before the start of the study procedures. For individuals aged 18 years and above, the informed consent form should be signed by the patient themselves or their immediate family members. Considering the patient's condition, if signing by the patient themselves is not conducive to treatment, the legal guardian or immediate family member should sign the informed consent form.
Exclusion Criteria:
* 1\. Uncontrolled infection at the time of enrollment, or requiring mechanical ventilation or hemodynamic instability;
* 2\. Severe organic damage: hepatic or renal impairment;
* 3\. Occurrence of any of the following within 6 months prior to the study: myocardial infarction, severe/unstable angina pectoris, congestive heart failure, or cerebrovascular accident, including transient ischemic attack;
* 4\. Presence of psychiatric disorders or other conditions that may compromise compliance with study treatment and monitoring requirements. Failure to sign the informed consent form;
* 5\. Inability or unwillingness to sign the consent form;
* 6\. Pa…
What they're measuring
1
Cumulative volume of red blood cell transfusions
Timeframe: 28 days post-HSCT
Trial details
NCT IDNCT07450313
SponsorInstitute of Hematology & Blood Diseases Hospital, China