CompletedNot Applicable

Periodontal Status and TMAO Levels in Peripheral Artery Disease

Turkey (Türkiye)61 participantsStarted 2022-02-15

Plain-language summary

This observational study aims to evaluate the association between periodontal status and trimethylamine-N-oxide (TMAO) levels in patients diagnosed with peripheral artery disease (PAD). Both serum and saliva TMAO concentrations will be measured and compared according to periodontal health, periodontitis, and edentulism status. Clinical periodontal examinations and biological sample collection will be performed. The study seeks to investigate whether oral health status is associated with systemic TMAO levels in individuals with PAD.

Who can participate

Age range18 Years

SexALL

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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: Inclusion Criteria: * Adults aged ≥18 years * Confirmed diagnosis of Peripheral Arterial Disease (PAD), defined as: Ankle-Brachial Index (ABI) \< 0.9 and/or angiographic or ultrasonographic evidence of arterial stenosis * No limb amputation * Presence of teeth and willingness to undergo full-mouth periodontal examination * Edentulous status with self-reported history of complete tooth loss due to advanced periodontitis * Ability to provide informed consent Exclusion Criteria: * Pregnant individuals * Use of oral contraceptives * Systemic antibiotic use within the previous 3 months * Corticosteroid use within the previous 3 months * Immunosuppressive therapy within the previous 3 months * Chronic non-steroidal anti-inflammatory drug (NSAID) use within the previous 3 months * Active periodontal treatment within the previous 6 months * Periodontal surgery within the previous 1 year

What they're measuring

Serum Trimethylamine-N-Oxide (TMAO) Levels (ng/ml)

Timeframe: At baseline (single time-point assessment)

Salivary Trimethylamine-N-oxide (TMAO) Level (ng/ml)

Timeframe: At baseline (single time-point assessment)

Trial details

NCT IDNCT07449546

SponsorAnkara University

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2024-01-10