Subjects will be provided a written informed consent to participate in the study and then undergo any screening. Subjects who meet all the inclusion criteria and none of the exclusion criteria based on the screening test results will be included into the study. At treatment day, the subjects will be administered 100 million cells of investigational product for 30 minutes for each package using a syringe pump. After 4 weeks (1 month) of Investigational product administration, the subjects will visit the study site to evaluate the safety and efficacy of investigational products. Follow up visits for potential efficacy will also be conducted after 12 weeks (3 months) and 24 weeks (6 months) of Investigational product administration. If necessary, additional examination and treatment may be performed according to the investigator's judgment
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Safety evaluation
Timeframe: 1, 3, and 6 months
Safety evaluation
Timeframe: 2 hours, 1 month, 3 months, and 6 months
Efficacy evaluation (Frailty state)
Timeframe: 1, 3, and 6 months
Efficacy evaluation (Patient quality of life)
Timeframe: 1, 3, and 6 months
Efficacy evaluation (Inflammatory biomarkers)
Timeframe: 1, 3, and 6 months
Efficacy evaluation (Inflammatory biomarkers)
Timeframe: 1, 3, and 6 months
Efficacy evaluation (Immune system biomarkers)
Timeframe: 1, 3, and 6 months
Efficacy evaluation (Immune system biomarkers)
Timeframe: 1, 3, and 6 months