Psilocybin Microdosing on Cognition, Mood and Quality of Life

Inclusion Criteria: * No history of psychedelic use * Able to read, speak, and understand English * Able and willing to provide written informed consent, and willing to commit to study protocol * Women of childbearing potential must be on a highly effective birth control method Exclusion Criteria: * Positive screen for recreational drugs or alcohol on test day will result in rescheduling the appointment * Current mood, developmental, or psychotic disorders (e.g., schizophrenia, affective disorders) per DSM-V * Current or past alcohol or substance use disorder per DSM-V * IQ \<70 on the Weschler Abbreviated Scale of Intelligence * Serious medical, neuro-ophthalmological, or neurological illness (e.g., cancer, seizure disorders, encephalopathy) * Current pregnancy, breastfeeding, or ineffective birth control methods * History of head trauma with loss of consciousness lasting \>30 minutes or concussion in last 30 days * Any medical/neurological condition that could compromise neurocognitive performance (e.g., epilepsy, multiple sclerosis, fetal alcohol syndrome) * Anyone deemed unsafe to study personnel for any reason; e.g., suicidal ideation * Focal brain lesion seen on structural MRI * MRI contraindications (e.g., implanted metallic object, severe claustrophobia)