Panic disorder (PD) is characterized by recurrent and unexpected panic attacks and is associated with significant functional impairment. Increasing evidence suggests involvement of immune-inflammatory mechanisms in PD. Elevated levels of inflammatory markers such as C-reactive protein (CRP) have been reported in PD; however, interleukin-33 (IL-33) and soluble suppressor tumorogenicity-2 (sST2), components of the IL-33/sST2 signaling axis, have not previously been investigated in PD. This cross-sectional case-control study aims to compare peripheral serum IL-33, sST2, and CRP levels between drug-naïve subjects diagnosed with PD and healthy controls (HCs). The findings may contribute to understanding the inflammatory mechanisms underlying PD.
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Interleukin-33 (IL-33)
Timeframe: At hospital admission (baseline)
Soluble Suppressor Tumorogenicity-2 (sST2)
Timeframe: At hospital admission (baseline)
C-Reactive Protein (CRP)
Timeframe: At hospital admission (baseline)
Mehmet Hamdi ÖRÜM, MD, Ass. Prof., Psychiatrist