Peripheral Nerve Blocks and Postoperative Pain and Mobilization After Total Knee Arthroplasty (NCT07442123) | Clinical Trial Compass
CompletedNot Applicable
Peripheral Nerve Blocks and Postoperative Pain and Mobilization After Total Knee Arthroplasty
Turkey (Türkiye)90 participantsStarted 2022-12-01
Plain-language summary
Total knee arthroplasty (TKA) is frequently associated with significant postoperative pain, which may delay early mobilization and negatively affect functional recovery. Peripheral nerve blocks are widely used as part of multimodal analgesia strategies to improve postoperative pain control while minimizing opioid consumption and preserving motor function. Different peripheral nerve block techniques may result in varying analgesic efficacy and mobilization outcomes.
The aim of this prospective observational study is to compare the effects of commonly used peripheral nerve block techniques on postoperative pain control and early mobilization in patients undergoing total knee arthroplasty under spinal anesthesia. Patients receiving fascia iliaca plane block are compared with those receiving a combination of adductor canal block and interspace between the popliteal artery and capsule of the knee (IPACK) block.
The primary outcome is postoperative opioid consumption within the first 24 hours after surgery. Secondary outcomes include postoperative pain scores assessed at predefined time intervals, early mobilization parameters, and opioid-related adverse effects. The findings of this study are intended to contribute to optimizing analgesic strategies and improving early functional recovery following total knee arthroplasty.
Who can participate
Age range
18 Years – 80 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Adult patients aged 18-80 years
* Scheduled for elective unilateral total knee arthroplasty
* Surgery performed under spinal anesthesia
* American Society of Anesthesiologists (ASA) physical status I-III
* Ability to understand the study procedures and provide informed consent
Exclusion Criteria:
* Refusal to participate
* Contraindications to spinal anesthesia or peripheral nerve block
* Known allergy to local anesthetics
* Chronic opioid use or opioid dependence
* Preexisting neurological or neuromuscular disorders affecting lower extremities
* Cognitive impairment preventing pain assessment
* Infection at the injection site
* Coagulopathy or ongoing anticoagulant therapy contraindicating regional anesthesia
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Total Postoperative Opioid Consumption
Timeframe: Within the first 24 hours after surgery
Trial details
NCT IDNCT07442123
SponsorDr Abdurrahman Yurtaslan Ankara Oncology Training and Research Hospital