Low-Flow Sevoflurane and Desflurane Anesthesia in Laparoscopic Cholecystectomy (NCT07440758) | Clinical Trial Compass
RecruitingNot Applicable
Low-Flow Sevoflurane and Desflurane Anesthesia in Laparoscopic Cholecystectomy
Turkey (Türkiye)70 participantsStarted 2026-03-20
Plain-language summary
Several studies have demonstrated that inhalational anesthetic agents such as desflurane and sevoflurane may cause varying degrees of postoperative sore throat, hoarseness, and cough in orotracheally intubated patients. However, data evaluating these outcomes under low-flow anesthesia conditions remain limited and insufficient.
This single-center, prospective, randomized controlled study will be conducted in patients aged 18-65 years, classified as American Society of Anesthesiologists (ASA) physical status I-II, who are scheduled to undergo elective laparoscopic cholecystectomy under general anesthesia and who provide written informed consent to participate in the study.
The primary objective of the study is to compare the effects of low-flow desflurane and low-flow sevoflurane anesthesia on the incidence and severity of postoperative sore throat.
The secondary outcomes include the evaluation of postoperative hoarseness and cough, the incidence of postoperative nausea and vomiting (PONV), and the total consumption of inhalational anesthetic agents.
Who can participate
Age range
18 Years – 65 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* American Society of Anesthesiologists (ASA) physical status I-II
* Aged between 18 and 65 years
* Patients who provide written informed consent to participate in the study
Exclusion Criteria:
* Patients with a recent history of upper respiratory tract infection
* Patients with a recent history of sore throat
* Patients with chronic cough
* Patients with a history of previous neck or tracheal surgery
* Patients with predictors of difficult intubation
* Patients with a history of difficult intubation
* Obese patients (BMI \> 35 kg/m²)
* Patients with chronic respiratory diseases (asthma, COPD)
* Pregnancy
* Use of dexamethasone
* Patients with hepatic impairment
* Patients with allergy to paracetamol, tramadol, granisetron, dexamethasone, or metoclopramide
* Patients with known allergy to halogenated anesthetic agents
* Patients with a history of malignant hyperthermia
* Patients with mental disorders or those unable to provide reliable assessment
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Presence and Severity of Postoperative Sore Throat