Not Yet RecruitingPhase 2

Evaluation of the Efficacy of Corticosteroids in Septic Arthritis in Adults

France200 participantsStarted 2026-03-30

Plain-language summary

Septic arthritis is a severe infection associated with significant morbidity and mortality. Despite eradication of the microorganisms, persistent inflammation may lead to substantial long-term functional joint sequelae. The use of corticosteroids could reduce this inflammation, thereby improving functional joint outcomes and facilitating first-line medical treatment. The hypothesis of this study is that corticosteroid administration, in addition to antibiotic therapy, reduces persistent inflammation and improves functional joint prognosis in adult patients with acute septic arthritis.

Who can participate

Age range18 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Age ≥ 18 years * Documented septic arthritis (microorganism identified intra-articularly by culture or PCR, or by turbid synovial fluid with positive Gram stain, or positive blood cultures) * Effective antibiotic therapy initiated within ≤ 3 days * Effective contraception for women of childbearing age during treatment period * Signed informed consent * Affiliation to the French national health insurance system * Ability to read, write, and understand French Exclusion Criteria: * Polyarticular septic arthritis (≥ 2 joints) * Septic arthritis of small joints (e.g., fingers: proximal interphalangeal joint (PIP), distal interphalangeal joints (DIP), MetaCarpoPhalangeal (MCP); toes: MTP) * Systemic sclerosis * Pyomyositis * Diabetic foot infection * Current corticosteroid therapy for another indication * Inability to take oral medication * Contraindication to corticosteroids * Associated endocarditis * Presence of prosthetic joint or osteosynthesis material in the affected joint * Septic shock * Severe soft tissue wound overlying the joint * Aplastic chemotherapy * Neutropenia (defined as neutrophils \< 500/mm³) * Mycobacterial infection * Fungal infection * Sickle cell disease * Current pregnancy * Breastfeeding women * Patients under legal protection (e.g., guardianship) * Participation in another interventional clinical trial * Uncontrolled diabetes * Unstable psychiatric disorders * Adults unable to provide informed consent * Contraindication to cortic…

What they're measuring

To assess the effect of adjunctive corticosteroid therapy added to standard antibiotic treatment on functional joint outcomes at 24 weeks in adult patients with acute septic arthritis.

Timeframe: 24 weeks

To assess the effect of adjunctive corticosteroid therapy added to standard antibiotic treatment on functional joint outcomes at 24 weeks in adult patients with acute septic arthritis.

Timeframe: 24 weeks

Trial details

NCT IDNCT07440238

SponsorAssistance Publique - Hôpitaux de Paris

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-09

Contact for this trial

Benjamin ROSSI, PhD

+33 1 45 21 37 58 benjamin.rossi@ght-gpne.fr

View on ClinicalTrials.gov More Septic Arthritis trials

Plain-language summary

Who can participate

Age range18 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

What they're measuring

To assess the effect of adjunctive corticosteroid therapy added to standard antibiotic treatment on functional joint outcomes at 24 weeks in adult patients with acute septic arthritis.

Timeframe: 24 weeks

To assess the effect of adjunctive corticosteroid therapy added to standard antibiotic treatment on functional joint outcomes at 24 weeks in adult patients with acute septic arthritis.

Timeframe: 24 weeks