Not Yet RecruitingNot Applicable

Septic Shock Hemodynamic Respond to Volume Resuscitation Versus Vasopressor Administration

Thailand180 participantsStarted 2026-03-15

Plain-language summary

The goal of this observational study is to learn about the change of hemodynamic response from intravenous fluid versus medical (vasopressor) resuscitation by echocardiogram in septic shock patient. The main question it aims to answer is: How hemodynamic response change from intravenous fluid versus medical (vasopressor) resuscitation by echocardiogram in septic shock patient? Participants already receiving the appropriate resuscitation at that time by their medical staff as part of their regular medical care for septic shock. The echocardiogram will assess before and after resuscitation.

Who can participate

Age range18 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Adult patients aged ≥18 years * Diagnosis with Septic Shock (Sepsis-3 Definition of Septic Shock) * Hypotension, SBP \< 90 mmHg, or mean arterial BP \< 65 mmHg Exclusion Criteria: * Patients who receive two or more vasopressors * Patients who receive inotropic medications * Patients who receive simultaneously fluid with vasopressor resuscitation * Patients with insufficiently quality ultrasound images for determining echocardiography * Patients or their legally authorized representatives (LAR), who decline participation in the study or are unable to provide informed consent before enrollment

What they're measuring

Change in Cardiac Index

Timeframe: T0 = Cardiac index before resuscitation T1= Cardiac index 15minutes after resuscitation by IV fluid or Vasopressor (Post-resuscitation)

Trial details

NCT IDNCT07438301

SponsorMahidol University

Sponsor typeOTHER

Study typeOBSERVATIONAL

Primary completion2026-12-31

Contact for this trial

Surat Tongyoo, MD

+66824198534 surat.ton@mahidol.ac.th