PRF + Minocycline vs Arestin in Non-surgical Perio Therapy (NCT07437209) | Clinical Trial Compass
CompletedPhase 4
PRF + Minocycline vs Arestin in Non-surgical Perio Therapy
United States15 participantsStarted 2024-12-01
Plain-language summary
Periodontitis is a chronic, biofilm-modulated inflammatory disease characterized by microbial dysbiosis and a dysregulated host immune response, eventually resulting in the gradual breakdown of the periodontal attachment apparatus. While non-surgical periodontal therapy (NSPT) remains the first choice of treatment, its capability to completely resolve inflammation and pocketing in moderate disease severity may be limited, supporting the use of adjunctive antimicrobial or biologic interventions. Platelet-rich fibrin (PRF) and locally administered antibiotics, including minocycline, have individually shown clinical advantages; nonetheless, evidence assessing their combined utility remains unexplored. This split-mouth randomized controlled clinical trial (RCT) aims to compare the clinical efficacy of PRF combined with minocycline versus minocycline microspheres hydrochloride (Arestin) as adjuncts to NSPT in patients with Stage II or III, Grade A or B periodontitis.
Who can participate
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Male and Female subjects requiring non-surgical periodontal therapy• No contraindications to periodontal treatment
Exclusion Criteria:
* previous periodontal treatment within the past 6 months;
* local or systemic antibiotic treatment within the past 3 months;
* diagnosis of Stage I/ or IV periodontitis;
* poor oral hygiene defined as a full-mouth plaque score \>30%;
* history of radiation or immunosuppressive therapy;
* presence of neurologic disorders, major mechanical obstruction to mouth opening, or acute temporomandibular capsulitis;
* systemic conditions that may compromise bone metabolism or wound healing such as metabolic bone disease, uncontrolled diabetes;
* history of substance abuse such as drug or alcohol; or
* current pregnancy, nursing, or planning pregnancy during the study period.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Clinical Attachment Loss
Timeframe: 6 months
2
Probing Depths
Timeframe: 6 months
3
Gingival Recession
Timeframe: 6 months
Trial details
NCT IDNCT07437209
SponsorCenter for Advanced Rejuvenation and Esthetics