Study of BPI-572270 in Patients With Advanced Solid Tumors Harboring Specific Mutations in RAS (NCT07435038) | Clinical Trial Compass
Not Yet RecruitingPhase 1/2
Study of BPI-572270 in Patients With Advanced Solid Tumors Harboring Specific Mutations in RAS
120 participantsStarted 2026-02-12
Plain-language summary
Evaluate the safety and tolerability of BPI-572270 in adult patients with specific RAS mutant advanced solid tumors.
Who can participate
Age range18 Years
SexALL
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Inclusion Criteria:
* Histologically confirmed advanced solid tumor with RAS mutations identified through deoxyribonucleic acid (DNA) sequencing.
* Have received prior standard therapy appropriate for tumor type and stage.
* Have Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1 Adequate organ function.
Exclusion Criteria:
* Primary central nervous system (CNS) tumors active and untreated brain metastases.
* Known or suspected impairment of gastrointestinal function that may prohibit ability to swallow or absorb an oral medication.
* History of any other unstable or clinically significant concurrent medical condition that would, in the opinion of the investigator, jeopardize the safety of a participant, impact their expected survival through the end of the study participation, and/or impact their ability to comply with the protocol prior/concomitant therapy