The Efficacy of Sesewanua (Clerodendrum Fragrans Wild) Mouthwash in Reducing Oral Bacteria Growth… (NCT07434882) | Clinical Trial Compass
CompletedNot Applicable
The Efficacy of Sesewanua (Clerodendrum Fragrans Wild) Mouthwash in Reducing Oral Bacteria Growth: A Quasi-Experimental Study in Nursing Practice
Indonesia100 participantsStarted 2025-06-19
Plain-language summary
Background and Objectives: This study investigated the antibacterial efficacy of Sesewanua (Clerodendrum fragrans Wild) extract as a mouthwash alternative to mitigate oral bacteria, particularly Streptococcus mutans.
Materials and Methods: A quasi-experimental design was employed with a cohort of 100 female students, divided into four groups to assess varying concentrations (1%, 2%, and 4%) of Sesewanua extract, along with a purified water control. The extraction process involved mechanical grinding followed by maceration with 70% ethanol to maximize the extraction of bioactive compounds. Microbiological analysis was conducted post-intervention to measure the reduction in bacterial counts.
Who can participate
SexFEMALE
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion criteria
✓. Female students registered as residents of the female dormitory at the Manado Ministry of Health Polytechnic during the study period.
✓. Age ≥17 years.
✓. Willing to sign written informed consent.
✓. Good oral and general health status based on initial screening (no acute oral infections, severely inflamed gums, or other oral conditions requiring immediate treatment).
✓. Not currently using medications or therapies that could modulate oral flora (e.g., systemic antibiotics, therapeutic oral antiseptics) in the past 2 weeks.
✓. Able to follow standardized oral hygiene protocols (able to brush and rinse as instructed).
Exclusion criteria
✕. Pregnancy or breastfeeding.
✕. History of allergy to ingredients in mouthwash formulations (e.g., fragrances, parabens, sorbitol).
✕. Use of antibiotics, antifungals, systemic steroids, or immunosuppressive medications in the 2 weeks before or during the study.
✕. Invasive dental treatment or oral surgery in the past 1 month.
What they're measuring
1
Change in Streptococcus mutans colony counts (CFU/ml) in participants' oral samples between pre-intervention and post-intervention. Secondary Outcome
Timeframe: Research timeline for a quasi-experimental study on the effectiveness of Sesewanua (Clerodendrum fragrans Wild) mouthwash in reducing the growth of Streptococcus mutans. Total duration: 12 weeks (3 months).
2
Outcome Measure 2 (Secondary A; continuous; %):
Timeframe: Research timeline for a quasi-experimental study on the effectiveness of Sesewanua (Clerodendrum fragrans Wild) mouthwash in reducing the growth of Streptococcus mutans. Total duration: 12 weeks (3 months).
Timeframe: Research timeline for a quasi-experimental study on the effectiveness of Sesewanua (Clerodendrum fragrans Wild) mouthwash in reducing the growth of Streptococcus mutans. Total duration: 12 weeks (3 months).