Comparison Of Clinical Outcomes of Intraperitoneal Bupivacaine Instillation Versus Placebo as Pre… (NCT07429448) | Clinical Trial Compass
RecruitingPhase 1
Comparison Of Clinical Outcomes of Intraperitoneal Bupivacaine Instillation Versus Placebo as Preemptive Analgesia in Patients Undergoing Open Appendectomy
Pakistan60 participantsStarted 2025-12-16
Plain-language summary
To compare the clinical outcomes of intraperitoneal bupivacaine instillation vs placebo as preemptive analgesia in patients undergoing open appendectomy
Who can participate
Age range20 Years – 60 Years
SexALL
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Inclusion Criteria:
* Patients presenting to the emergency department undergoing open appendectomy.
Exclusion Criteria:
* Patients undergoing interval appendectomy or having perforated appendix as evident by examination (abdominal tenderness/ fever) and USG findings (presence of abscess, fluid collection, or free air).
* Uncontrolled medical disease (DM: BSL \>200mg/dl, HTN: BP \>140/90)
* History of chronic kidney or liver disease/ psychiatric illness/ Active peptic ulcer disease (as determined on history and medical records)
* Alcoholics
* History of chronic pain or patients on analgesic medications
* Pregnant females
* History of allergy to bupivacaine/ ketorolac as determined on history
* Children, Adolescents and patients with mental illness.