CompletedNot Applicable

Minimal-flow Anesthesia and Cognitive Outcomes in Elderly Surgical Patients

Turkey (Türkiye)90 participantsStarted 2025-10-03

Plain-language summary

Purpose: Postoperative cognitive dysfunction (POCD) is a common complication in elderly patients following major surgery and is associated with impaired attention, memory, and executive functions. Advanced age and prolonged surgical duration are among the most important risk factors. Minimal flow anesthesia has been suggested to reduce postoperative cognitive impairment by providing more stable anesthetic depth and reducing physiological stress. The aim of this study is to investigate the relationship between surgical duration and postoperative cognitive dysfunction in elderly patients undergoing surgery under minimal flow anesthesia.

Who can participate

Age range

65 Years – 85 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria:Inclusion Criteria: * Patients aged between 65 and 85 years * ASA physical status I-III * Scheduled for elective surgery under general anesthesia in general surgery or otorhinolaryngology operating rooms * Planned to receive minimal flow general anesthesia * Preoperative Mini-Mental State Examination performed * Able to provide informed consent Exclusion Criteria: * Age outside the specified range * ASA physical status IV or higher * Severe comorbid disease affecting perioperative stability * Surgery performed under regional anesthesia * History of alcohol, drug, or substance abuse * Significant visual or hearing impairment interfering with cognitive testing * Refusal to participate * Known neurological or psychiatric disorders * Preoperative MMSE score below 24 * Perioperative hemodynamic instability * Illiteracy preventing completion of cognitive tests * Postoperative admission to intensive care unit Exclusion Criteria: \-

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Change in Mini-Mental State Examination score

Timeframe: Preoperative baseline, postoperative 24 hours, and postoperative day 7

Trial details

NCT IDNCT07424729

SponsorAnkara Etlik City Hospital

Sponsor typeOTHER_GOV

Study typeINTERVENTIONAL

Primary completion2026-03-12

View on ClinicalTrials.gov More Postoperative Cognitive Dysfunction trials