This is a single-center clinical study aiming to improve gait functions in patients with Parkinson's Disease (PD) by using adaptive neurostimulation to the pallidum. The investigators will use a bidirectional deep brain stimulation device with sensing and stimulation capabilities to 1) identify neural biomarkers to detect the onset of walking by recording neural activities from the motor cortical areas and the globus pallidus, 2) understand the impacts of changes in DBS parameters on gait kinematics and optimize setting parameters for enhancing walking performance, 3) develop a movement state-dependent adaptive deep brain stimulation (DBS) paradigm to automatically switch stimulation settings according to different movement states (i.e., walking vs non-walking). The proposed therapy will deliver personalized neurostimulation based on individual physiological biomarkers to enhance gait function in patients with PD. 6 patients with idiopathic Parkinson's disease who have already been implanted with the Medtronic Summit RC+S device will be enrolled in this study.
Age range
21 Years – 75 Years
Sex
ALL
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A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
Change in Mini Balance Evaluation Systems Test (Mini-BESTest) Scores
Timeframe: after each 7 day block
Change in Gait
Timeframe: 14 day long-term testing period
Change in Movement Disorders Society Unified Parkinson's Disease Rating Scale (MDS-UPDRS) III scores
Timeframe: after each 7 day block
Change in Stride Length
Timeframe: 14 day long-term testing period
Change in Stride Time
Timeframe: 14 day long-term testing period
Change in Double Support Time
Timeframe: 14 day long-term testing period
Change in number of freezes
Timeframe: 14 day long-term testing period
Change in number of falls
Timeframe: 14 day long-term testing period
Change in Activities-Specific Balance Confidence (ABC) Scale
Timeframe: once per day during 14 day long-term testing period