Representation of Spatiotemporal Information in Human Episodic Memory and Navigation (NCT07423923) | Clinical Trial Compass
By InvitationEarly Phase 1
Representation of Spatiotemporal Information in Human Episodic Memory and Navigation
United States15 participantsStarted 2025-04-01
Plain-language summary
Neural diseases such as stroke can have distinct effects on the ability to navigate and orient compared to remembering daily events like when one last took medicine. This proposal seeks test rival hypotheses regarding the neural mechanisms underlying commonalities and differences in navigation and event-related memory, particularly as they relate to pre-existing knowledge. Such mechanistic insight could help inspire therapies that could be used to bolster intact brain function in a compensatory manner following strokes or other neural insults.
Who can participate
Age range18 Years – 40 Years
SexALL
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Inclusion criteria
✓. Able to provide verbal and written informed consent
✓. Fluent English speaker
✓. At least 8th grade education
✓. Age between 18-40 years.
✓. Normal or corrected-to-normal eyesight
Exclusion criteria
✕. Magnetic resonance imaging contraindications (e.g., metallic objects in body, claustrophobia)
✕. Current use of anticonvulsant, neuroleptic, sedatives, or other medications known to affect cognition
✕. Neurologic conditions affecting the brain (e.g., stroke, epilepsy, traumatic brain injury with loss of consciousness)
✕. Psychiatric conditions (e.g., major depression, schizophrenia)
✕. Patients with gross structural abnormalities (hematoma, tumors, large vascular malformations, diffuse malformations of cortical development) that may impact critical perceptual or memory areas needed to perform tasks.
What they're measuring
1
behavioral: navigational accuracy
Timeframe: from enrollment to end of study (3 days)
2
intracranial EEG low-frequency oscillatory power
Timeframe: from enrollment to the end of study (3 days)
3
memory accuracy (as part of memory training component involving healthy controls)
Timeframe: from enrollment to the end of study (3 weeks)
4
Route replay time
Timeframe: from enrollment to the end of study (3 days)
✕. Patients who are unable to participate in memory testing due to impaired cognition or mental retardation. All patients routinely undergo a detailed neuropsychological evaluation, and the neuropsychological report will be used to make this assessment.
✕. Patients/volunteers with cardiac pacemakers, intracranial aneurysm clips, or other potentially mobile implanted metallic devices cannot be included in this study, because of possible effects of high power magnetic fields on them.
✕. Patients with claustrophobia who cannot undergo an MRI scan without sedation.