The purpose is to investigate if a strategy of routine OCT based diagnosis and guidance of PCI improves clinical outcomes compared with a standard strategy of guidance by angiography in patients presenting with ACS
Who can participate
Age range18 Years
SexALL
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Inclusion Criteria:
Clinical inclusion criteria:
* NSTEMI, STEMI
* Symptom duration \<12h for STEMI and \<48h for NSTEMI
* Age ≥ 18yrs
* Ability to provide written informed consent
Angiographic inclusion criteria:
* Angiographic signs of at least one possible culprit lesion. Signs including acute occlusion, partial occlusion, proximal embolus, haziness, high grade stenosis, stent thrombosis
* Wire in true distal lumen
Exclusion Criteria:
Clinical exclusion criteria
* Intravascular imaging evaluation of any lesions at index procedure
* Cardiogenic shock
* Sustained ventricular tachycardia or ventricular fibrillation
* Planned CABG
* Life expectancy \<1 year
* Known severe heart failure with NYHA class equal or above III
* Known ejection fraction \<30% before the admission
* Known renal failure with GFR \<30 ml/min/1.73 m2
* Active bleeding or coagulopathy
* Relevant allergies (contrast media, aspirin, clopidogrel, ticagrelor, everolimus)
* Suspected inability to lie flat for the duration of the PCI procedure
* Inability to comply with the planned follow-up program
* Known or anticipated compliance problems with medical therapy
Angiographic exclusion criteria
* Study lesion involving the Left main coronary artery
* Study lesion involving a true bifurcation lesion with a SB \>2.5mm
* Severe tortuosity
* Distal embolus
* Isolated coronary artery spasm
* Suspected spontaneous coronary artery dissection
* Chronic total occlusions with treatment indication and no antegrade …
What they're measuring
1
Combined endpoint of major adverse cardiac events (MACE)