RecruitingNot Applicable

PRE-hospital Cooling to improvE carDiac arrEst Neurological outComEs (PRECEDENCE)

Singapore50 participantsStarted 2026-02-01

Plain-language summary

The PRE-hospital Cooling to improvE carDiac arrEst Neurological outComEs (PRECEDENCE) study is a pilot feasibility trial evaluating the implementation of pre-hospital targeted temperature management (TTM) using a wearable surface cooling device (CarbonCool® vest) in adult out-of-hospital cardiac arrest (OHCA) patients with return of spontaneous circulation (ROSC). The study aims to assess feasibility, fidelity, acceptability, and safety of initiating cooling in the field by emergency medical services (EMS) prior to hospital arrival. Results will inform the design of a larger definitive trial to determine the clinical effectiveness of early pre-hospital TTM in improving neurological outcomes.

Who can participate

Age range

16 Years – 80 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

. Out-of-hospital cardiac arrest (OHCA) of any rhythm attended by Singapore Civil Defence Force (SCDF) paramedics.
. Return of spontaneous circulation (ROSC) achieved in the pre-hospital setting.
. Age ≥16 years and ≤80 years.
. Patient remains comatose after ROSC, with Glasgow Coma Scale (GCS) ≤8.

Exclusion criteria

. Age \>80 years.
. Traumatic cause of cardiac arrest.
. Tympanic temperature \<34°C at time of assessment.

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

Recruitment feasibility

Timeframe: Through study completion, anticipated to be one year

Intervention feasibility

Timeframe: Through study completion, anticipated to be one year

Proportion of cases with complete adherence of workflow and case report forms

Timeframe: Through study completion, anticipated to be one year

Acceptability of Intervention Measure (AIM)

Timeframe: Time frame within 3 months of case recruitment

Intervention Appropriateness Measure (IAM)

Timeframe: Time frame within 3 months of case recruitment

Feasibility of Intervention Measure (FIM) scores

Timeframe: Time frame within 3 months of case recruitment

Trial details

NCT IDNCT07421882

SponsorSingapore General Hospital

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-12

Contact for this trial

Shir Lynn Lim, MBBS

+65 91760383 shir.lynn.lim@nus.edu.sg

View on ClinicalTrials.gov More Out-Of-Hospital Cardiac Arrest trials

Plain-language summary

Who can participate

Age range

16 Years – 80 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

. Out-of-hospital cardiac arrest (OHCA) of any rhythm attended by Singapore Civil Defence Force (SCDF) paramedics.
. Return of spontaneous circulation (ROSC) achieved in the pre-hospital setting.
. Age ≥16 years and ≤80 years.
. Patient remains comatose after ROSC, with Glasgow Coma Scale (GCS) ≤8.

Exclusion criteria

. Age \>80 years.
. Traumatic cause of cardiac arrest.
. Tympanic temperature \<34°C at time of assessment.

What they're measuring

Recruitment feasibility

Timeframe: Through study completion, anticipated to be one year

Intervention feasibility

Timeframe: Through study completion, anticipated to be one year

Proportion of cases with complete adherence of workflow and case report forms

Timeframe: Through study completion, anticipated to be one year

Acceptability of Intervention Measure (AIM)

Timeframe: Time frame within 3 months of case recruitment

Intervention Appropriateness Measure (IAM)

Timeframe: Time frame within 3 months of case recruitment

Feasibility of Intervention Measure (FIM) scores

Timeframe: Time frame within 3 months of case recruitment