The PRE-hospital Cooling to improvE carDiac arrEst Neurological outComEs (PRECEDENCE) study is a pilot feasibility trial evaluating the implementation of pre-hospital targeted temperature management (TTM) using a wearable surface cooling device (CarbonCool® vest) in adult out-of-hospital cardiac arrest (OHCA) patients with return of spontaneous circulation (ROSC). The study aims to assess feasibility, fidelity, acceptability, and safety of initiating cooling in the field by emergency medical services (EMS) prior to hospital arrival. Results will inform the design of a larger definitive trial to determine the clinical effectiveness of early pre-hospital TTM in improving neurological outcomes.
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Recruitment feasibility
Timeframe: Through study completion, anticipated to be one year
Intervention feasibility
Timeframe: Through study completion, anticipated to be one year
Proportion of cases with complete adherence of workflow and case report forms
Timeframe: Through study completion, anticipated to be one year
Acceptability of Intervention Measure (AIM)
Timeframe: Time frame within 3 months of case recruitment
Intervention Appropriateness Measure (IAM)
Timeframe: Time frame within 3 months of case recruitment
Feasibility of Intervention Measure (FIM) scores
Timeframe: Time frame within 3 months of case recruitment