This phase I/II trial studies the side effects and best dose of ABBV-383 and to see how well it works in treating patients with Waldenström macroglobulinemia that has come back after a period of improvement (relapsed) or that does not respond to treatment (refractory). ABBV-383 is a monoclonal antibody that may interfere with the ability of cancer cells to grow and spread. A monoclonal antibody is a type of protein that can bind to certain targets in the body, such as molecules that cause the body to make an immune response (antigens).
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Maximum tolerated dose (MTD) of etentamig (ABBV-383) (Phase 1)
Timeframe: Up to 1 cycle (Cycle length = 28 days)
Very good partial response (VGPR) or better response as the best response achieved (Phase 2)
Timeframe: Within 12 cycles of initiation of therapy (Cycle length = 28 days)