Restoring Facial Volume After GLP-1 Weight Loss With Radiesse

Inclusion Criteria: * Adults aged 21-65 who are initiating GLP-1 therapy (semaglutide, tirzepatide, or similar) for weight loss or diabetes-related weight management with targeted weight loss of 20 pounds or more * Participants must have a body mass index (BMI) meeting indications for GLP-1 therapy and within the range of 24-32 * Participants should be at the start of GLP-1 therapy (baseline visit scheduled at or within 1-2 weeks of first GLP-1 injection) so that baseline facial measurements represent their pre-weight-loss state * Participants must have noticeable facial subcutaneous fat (no pre-existing extreme lipoatrophy) and be willing to receive facial filler injections * Participants should be able to comply with all study visits and procedures up to 12 months * Participants must provide written informed consent, including consent for facial imaging Exclusion Criteria: * Participants with any prior facial cosmetic procedures that could confound results e.g. facial filler or fat transfer in the past 2 years; thread lifts or energy based device facial treatments in the last 1 year; microneedling, botulinum toxin treatment in the depressor anguli oris (DAO), or chemical peels in the last 4 months; or a history of surgical lifts and/or liposuction * Participants currently using a retinoid * Participants with active dermatologic conditions affecting the face (e.g. severe acne, psoriasis on face) or scars that would interfere with volume assessment * Participants with know…