This Study Investigates β-hydroxy-β-methylbutyrate (HMB) and 2-hydroxybenzylamine (2-HOBA), When … (NCT07419633) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
This Study Investigates β-hydroxy-β-methylbutyrate (HMB) and 2-hydroxybenzylamine (2-HOBA), When Administered Either Individually or in Combination Contributes to an Increased Quality of Health, Specifically Improving Muscular Strength and Cognitive Functioning in Adults Over the Age of 65.
Canada120 participantsStarted 2026-02-05
Plain-language summary
In this study, participants will be assigned to receive HMB, 2-HOBA, a combination of both, or a comparison supplement for a set period of time. During the study, participants will attend scheduled visits where researchers will assess muscle strength, physical function, and overall health. Blood samples may be collected to measure markers related to metabolism, inflammation, and oxidative stress. Study staff will also monitor safety and any side effects throughout the study.
Who can participate
Age range65 Years
SexALL
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Inclusion Criteria:
•. 65 years of age
* English or French speaking
* Females not of childbearing potential
* Willing to maintain current lifestyle and dietary habits, including level of physical activity, allowed medication/supplements habits for the duration of the study
Exclusion Criteria:
* Known cardiac diseases, known arterial fibrillation, hepatic diseases, immune diseases (e.g. Individuals with an acute infectious disease, autoimmune disease or are immune compromised), ulcers, asthma, gout, severe anemia, hay fever, nasal polyps.
* Chronic kidney disease \[estimated glomerular filtration rate (GFR) \< 35 mL/min\].
* Neurological injury/disorder with significant persistent neurological or functional deficit (e.g., stroke with hemiparesis, spinal cord injury, muscular dystrophy, myopathy, myasthenia gravis, Parkinson's disease, peripheral polyneuropathy).
* Neuropsychological condition and/or cognitive impairment that, in the QI's opinion, could interfere with study participation
* History of confirmed chronic obstructive pulmonary disease with a severity grade \> 2 on the Medical Research Council Dyspnea Scale.
* Uncontrolled hypothyroidism or hyperthyroidism. Hypothyroid patients who have changed their dose of hormone replacement therapy in the 6 weeks before screening are not eligible.
* Underlying muscle diseases, including a history of or currently active myopathy (e.g., dermatomyositis, polymyositis, etc.) or muscular dystrophies.
* Confirmed rh…
What they're measuring
1
Effect of 90 days of HMB and/or 2-HOBA supplements when administered either individually or in combination on muscle mass.
Timeframe: 12 weeks
Trial details
NCT IDNCT07419633
SponsorMcGill University Health Centre/Research Institute of the McGill University Health Centre