Comparison of Customized Allogenic Versus Autogenous Bone Block Graft for Alveolar Ridge Augmentation

INCLUSION CRITERIA * 1-4 missing teeth that need to be replaced with dental implants * Bone ridge width insufficient for dental implant placement; \<5 mm of width as measured in a cone beam computed tomography at the ideal prosthetic position * Medically healthy with no known allergies to antibiotics * Non-smoker or light smoker (\< 10) or previous smoker who had quit for 5 years or more * Periodontal health, as confirmed by clinical examination (Full mouth bleeding score and full mouth plaque score \< 25%) and at least one neighboring natural tooth to the defect site(s) * Age of 18 or above EXCLUSION CRITERIA * All contraindications against implant treatment or augmentative procedures (e.g., advanced systemic diseases, corticosteroid medication, immunodeficiency, pregnancy, intention to become pregnant, breastfeeding, lack of safe contraception) * Treatments or diseases that may have an effect on bone turnover or the bone itself or non-mineralized tissue metabolism (e.g., bisphosphonates or local radiotherapy, skeletal immaturity) * Pathological fractures such as those observed in (but not limited to) Paget's disease or in metastatic bone diseases * Any active malignancy or patient undergoing treatment for a malignancy Study protocol: IndiALLO Version 4/19.03.2025 Page 9 von 32 * Contraindications to the class of drugs under study, e.g., known hypersensitivity or allergy to class of drugs or the investigational product * Persistent compartment syndrome or neurovascular re…