Effects of Repeated Electroconvulsive Therapy Sessions on Anesthetic Requirements (NCT07418463) | Clinical Trial Compass
CompletedNot Applicable
Effects of Repeated Electroconvulsive Therapy Sessions on Anesthetic Requirements
Turkey (Türkiye)60 participantsStarted 2026-03-15
Plain-language summary
Electroconvulsive therapy (ECT) is an effective treatment for severe depression and other psychiatric disorders. ECT is usually given in several sessions on different days. During each session, patients receive short-acting anesthesia to ensure comfort and safety.
This study aims to evaluate whether the amount of anesthetic medication required changes during repeated ECT sessions in the same patient. In addition, the study will examine the relationship between anesthetic dose, seizure duration, seizure quality (measured by postictal suppression index), and recovery time.
This is a prospective observational study. All anesthesia and ECT procedures will be performed according to routine clinical practice. No additional intervention will be applied for research purposes.
Who can participate
Age range
18 Years – 65 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Age 18 to 65 years.
* Scheduled to undergo electroconvulsive therapy (ECT) under elective conditions as part of routine clinical care.
* ECT indication (e.g., major depressive disorder, bipolar depression, schizoaffective disorder, catatonia).
* ASA Physical Status I-III.
* Planned to receive multiple ECT sessions.
* Able to provide written informed consent (participant and/or legally authorized representative).
Exclusion Criteria:
* Use of antiepileptic drugs or benzodiazepines that may affect seizure threshold.
* ECT received within the past 6 months.
* Severe cardiovascular, pulmonary, or neurologic comorbidity (investigator judgment).
* Pregnancy or breastfeeding.
* ASA Physical Status IV or higher.
* Acute substance or alcohol use disorder/intoxication.
* Conditions preventing EEG monitoring (e.g., scalp trauma, significant skin lesions, cranial implants).
* Inability to obtain reliable BIS monitoring during anesthesia induction due to technical limitations.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Change in Anesthetic Dose Requirement Across Repeated ECT Sessions
Timeframe: Across the first 4 ECT sessions per participant (from Session 1 to Session 4), during the study period (up to 3 months).