Continued Pressure for Alveolar Protection (CPAP Trial) (NCT07417111) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
Continued Pressure for Alveolar Protection (CPAP Trial)
860 participantsStarted 2026-05-31
Plain-language summary
The objective of the CPAP Trial is to test whether extending CPAP until 34 weeks' PMA or for at least 2 additional weeks compared to weaning to a nasal canula will decrease the likelihood of bronchopulmonary dysplasia or death at 36 weeks' PMA.
Who can participate
Age range31 Weeks
SexALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Gestational age \<29 weeks at birth
* PMA \<32 weeks at study entry
* On treatment with CPAP without a rate in FiO2 \<0.25 and PEEP of 4-5 cmH2O
* Meet stability criteria:
* If previously intubated must be extubated ≥ 72 hours
* \<3 self-resolving apneas (≤ 20 s) and/or bradycardia (\<100 bpm) in any hour over previous 6 hours
* No episodes of apnea or bradycardia requiring intervention (oxygen/stimulation/bag and mask) for 24 hours
* Parents/legal guardians consent for enrollment
Exclusion Criteria:
* Major malformation
* Neuromuscular condition that affects respiration
* Terminal illness
* Decision to withhold or limit support
* Too sick to participate in opinion of Attending physician
* Clinical shock, sepsis
* Planned surgery during study period