Not Yet RecruitingEarly Phase 1

A Clinical Study Evaluating the Safety and Preliminary Efficacy of Universal Allogeneic CAR T-cell Therapy Targeting CD19 and BCMA(QT-019C)in Patients With Refractory Primary Immune Thrombocytopenia

China27 participantsStarted 2026-02-20

Plain-language summary

This is an investigator-initiated trial to evaluate the safety and efficacy of universal allogeneic anti-CD19/BCMA CAR T-cells(QT-019C) in Patients With Refractory Primary Immune Thrombocytopenia.

Who can participate

Age range

18 Years – 75 Years

Sex

ALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion criteria

. Echocardiogram indicates ejection fraction \>50%, ECG shows no significant abnormalities;
. Creatinine clearance (CrCl) (Cockcroft-Gault formula) \>30 mL/min;
. Alanine aminotransferase (ALT) and aspartate aminotransferase (AST) \<3.0x the upper limit of normal (ULN);
. Total bilirubin (TBIL) and alkaline phosphatase (AKP or ALP) \<2.0x ULN (Gilbert's syndrome \<3.0x UN);
. Absolute lymphocyte count (ALC) \>0.5x10\^9; absolute neutrophil count (ANC) \>1x10\^9; hemoglobin (Hb) \>60g;
. Oxygen saturation \>92%.

Exclusion criteria

Questions worth asking your doctor

Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.

1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?

Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.

Questions for the trial coordinator

The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.

1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?

A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.

What they're measuring

The number and severity of dose-limiting toxicity (DLT)events

Timeframe: Within 28 Days After QT-019C infusion

The total number, incidence, and severity of Adverse Events(AEs)

Timeframe: Within 28 Days After QT-019C infusion

Trial details

NCT IDNCT07416032

SponsorUnion Hospital, Tongji Medical College, Huazhong University of Science and Technology

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2028-06-20

Contact for this trial

Heng Mei, Ph.D&M.D

027-8572600 hmei@hust.cdu.cn

View on ClinicalTrials.gov More Immune Thrombocytopenia (ITP) trials