JKN2306 in Healthy Subjects: Single Ascending Dose and Food Effect Study

Inclusion Criteria: * Healthy Chinese males or females aged 18 to 55 years (inclusive). * Body weight ≥50 kg for males and ≥45 kg for females; BMI 19.0 to 28.0 kg/m² (inclusive). * Able and willing to comply with study procedures and restrictions and to complete the study as planned. * Willing to use medically acceptable contraception and have no plan for pregnancy, sperm donation, or oocyte donation from signing informed consent through 90 days after the last dose. Exclusion Criteria: * Participation in another clinical trial within 3 months prior to screening or planned participation during the study. * Clinically significant diseases or abnormalities that may affect safety or study participation; or conditions that may interfere with absorption, distribution, metabolism, or excretion (e.g., relevant gastrointestinal disorders). * History of photosensitivity or hypersensitivity/allergy to study drug components, other drugs, or foods. * Serious infection/major trauma/major surgery within 3 months prior to dosing, or planned surgery during the study; febrile illness or evidence of active infection within 2 weeks prior to first dose. * Use of medications that may affect hepatic drug metabolism within 28 days; use of prescription/OTC drugs, herbal products, vitamins, or supplements within 14 days prior to dosing or planned use during the study. * Consumption of grapefruit-related products/caffeine/alcohol and other specified dietary restrictions within 48 hours prior to firs…