Ozone Injection vs ESWT for Chronic Achilles Tendinopathy (NCT07412652) | Clinical Trial Compass
CompletedNot Applicable
Ozone Injection vs ESWT for Chronic Achilles Tendinopathy
Turkey (Türkiye)63 participantsStarted 2025-05-02
Plain-language summary
This randomized controlled clinical trial compares ultrasound-guided local ozone injection, extracorporeal shock wave therapy, and conventional conservative treatment in patients with chronic Achilles tendinopathy. The study focuses on changes in pain, functional outcomes, and overall clinical improvement during the follow-up period.
Who can participate
Age range
18 Years – 65 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
Patients aged 18 to 65 years.
Patients with a diagnosis of Achilles tendinopathy confirmed by ultrasonography or magnetic resonance imaging (MRI).
Patients with persistent symptoms despite completion of conservative treatment.
Volunteers who agree to participate in the study.
Exclusion Criteria:
Patients with symptoms lasting less than 12 weeks.
Presence of contraindications to extracorporeal shock wave therapy (ESWT), including pregnancy; history of thrombosis; use of anticoagulant medications; coagulation disorders such as hemophilia; systemic conditions; or localized conditions at the treatment site such as active infection or malignant tumors.
Presence of contraindications to local ozone injection, including pregnancy; glucose-6-phosphate dehydrogenase (G6PD) deficiency; favism; uncontrolled hyperthyroidism; thrombocytopenia; severe cardiovascular conditions; and use of angiotensin-converting enzyme (ACE) inhibitors.
History of neurological disease, muscle disease, or peripheral vascular disease.
Presence of congenital or acquired deformities of the knee and/or ankle.
Receipt of physical therapy modalities applied to the Achilles tendon within the last 6 weeks.
Receipt of any therapeutic injection to the Achilles tendon within the last 12 weeks.
History of direct trauma to the symptomatic Achilles tendon or Achilles tendon rupture.
History of surgical treatment involving the Achilles tendon or ankle for any reason.
History of foot or ank…
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Pain intensity (Visual Analog Scale, VAS)
Timeframe: Baseline, post-treatment, and 12 weeks after treatment
2
Pain intensity assessed by Visual Analog Scale (VAS)
Timeframe: Baseline, post-treatment, and 12-week follow-up