Comparison of Anesthetic Efficacy OF 2% Lidocaine Inferior Alveolar Nerve (IANB) Block Versus Pri… (NCT07409896) | Clinical Trial Compass
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Comparison of Anesthetic Efficacy OF 2% Lidocaine Inferior Alveolar Nerve (IANB) Block Versus Primary Buccal Infilteration With 4% Articaine in Symptomatic Irreversible Pulpitis(SIP) IN Mandibular First Molars
Pakistan330 participantsStarted 2026-02-01
Plain-language summary
This randomized controlled trial aims to compare the anesthetic efficacy of 2% lignocaine administered through an inferior alveolar nerve block (IANB) in one group of participants with 4% articaine delivered via primary buccal infiltration in other group in patients with symptomatic irreversible pulpitis in mandibular first molars.
Who can participate
Age range18 Years – 55 Years
SexALL
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AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Systemically healthy patients classified as ASA I, aged 18-55 years.
* Permanent mandibular first molar tooth requiring endodontic therapy.
* Diagnosed with symptomatic irreversible pulpitis without swelling or sinus.
* Normal periapical radiographic appearance (no evidence of periapical pathology).
* Moderate pain as assessed by the Heft-Parker VAS (\>54 mm and \<114 mm).
* Lingering pain or prolonged response to cold testing (lasting more than 10 seconds).
* Positive response to electric pulp testing.
* Outcome assessed must be pulpal anesthesia
Exclusion Criteria:
* • Pregnant or lactating mothers.
* Teeth with reversible pulpitis, previously treated, or with calcified canals.
* Teeth with severe periodontal disease or periapical radiolucency.
* Patients who have taken analgesics or anti-inflammatory drugs within 6 hours before the treatment visit.
* Patients on medications that could potentially interact with the anesthetic solution (e.g., antihypertensives, anticoagulants).
* History of allergy to 4% articaine, lidocaine, or epinephrine.
* Systemic diseases, immunocompromised states, or significant anxiety/mental health disorders.
* History of vasovagal syncope on local anesthetic administration
What they're measuring
1
Anesthetic efficacy
Timeframe: 1 hour after administration of anesthetic agent
Trial details
NCT IDNCT07409896
SponsorArmed Forces Institute of Dentistry, Pakistan
Sponsor typeOTHER
Study typeINTERVENTIONAL
Primary completion2026-08-01
Contact for this trial
Dr. Sadia Shehzadi Dr. Sadia Shehzadi, BDS,FCPS(PG3)