Growth and Feeding Tolerance in Premature Infants (NCT07409038) | Clinical Trial Compass
Not Yet RecruitingNot Applicable
Growth and Feeding Tolerance in Premature Infants
Pakistan96 participantsStarted 2026-02-01
Plain-language summary
The main purpose of the study is to evaluate the effect of early human milk fortification versus delayed fortification on growth and feeding tolerance in premature infants.
Who can participate
Age range28 Weeks – 31 Weeks
SexALL
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Inclusion Criteria:
* Preterm infants born at 28-31+6 weeks' gestation and/or birth weight1000-1500g.
* Exclusively receiving mother's own milk or donor human milk.
* No major congenital anomalies, severe sepsis, or NEC at enrollment.
* Parental/guardian consent
Exclusion Criteria:
* Extremely pre-term infants
* Infants with congenital gastrointestinal malformations or metabolic disorders.
* Infants with confirmed necrotizing enterocolitis(NEC)Stage II/III or intestinal perforation before enrollment (as these cases indicate significant gastrointestinal morbidity that may interfere with feeding tolerance and growth assessment).
* Infants whose parents decline participation.
What they're measuring
1
weight gain
Timeframe: 2 to 3 months
2
● Linear growth & head circumference
Timeframe: 2 to 3 months
Trial details
NCT IDNCT07409038
SponsorChildren's Hospital and Institute of Child Health, Multan