The goal of this prospective interventional study is to improve the detection of subclinical chronic Cancer Therapy-Related Cardiovascular Toxicity (CTRCT) and evaluate the added value of advanced cardioechography, ergospirometry, and specific biomarkers in pediatric cancer survivors (aged 2 to 25) who received potentially cardiotoxic treatments (chemotherapy/thoracic radiotherapy). The main questions it aims to answer are: * Can advanced echocardiography (including strain and myocardial work), ECG, and ergospirometry effectively diagnose earlier subclinical cardiac impairment in this population? * What is the prevalence of cardiovascular risk factors (including physical activity levels and biological markers like proBNP/troponins) * Can new genetic or biological markers be identified to help optimizing the detection of CTRCT? At time of follow-up, if they agree, participants will: * Complete validated questionnaires regarding quality of life, physical activity, and sedentary behavior. * Undergo a cardiopulmonary exercise test (ergospirometry) for those aged over 8 years. * Wear an accelerometer (ActiGraph GT3X) for 7 consecutive days to monitor physical activity. * Provide an additional blood sample during routine follow-up for the creation of a biobank dedicated to analyzing markers of senescence, fibrosis, apoptosis, and genetic polymorphisms.
Age range
2 Years – 25 Years
Sex
ALL
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A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
EKG anomaly
Timeframe: At inclusion (single study visit)
Echocardiography anomaly: systolic dysfunction
Timeframe: At inclusion (single study visit)
Echocardiography anomaly: diastolic dysfunction
Timeframe: At inclusion (single study visit)
Echocardiography anomaly: Significant alteration in myocardial deformation
Timeframe: At inclusion (single study visit)
Echocardiography anomaly: myocardial work indices
Timeframe: At inclusion (single study visit)
Echocardiography anomaly: valvular disease or heart inflammation
Timeframe: At inclusion (single study visit)
Cardiopulmonary Exercise Testing (CPET): Impaired functional capacity
Timeframe: At inclusion (single study visit)