Exercise, Insulin Resistance, and Chronic Pain in Postmenopausal Women.

Inclusion Criteria: * Postmenopausal women, defined as between 12 months and 5 years since the last menstrual period. * Not using hormone replacement therapy. * Not engaged in regular physical exercise (defined as more than once per week in the last months). * With or without insulin resistance. Exclusion Criteria: * Diagnosis of neurological diseases (e.g., Parkinson's disease, multiple sclerosis, or stroke sequelae). * Severe psychiatric disorders. * Inflammatory autoimmune diseases (e.g., rheumatoid arthritis or systemic lupus erythematosus). * Active neoplasms. * Use of systemic corticosteroids or immunosuppressive drugs within the last three months. * Severe decompensated cardiovascular disease. * Any medical condition that contraindicates participation in physical exercise.