A Phase 3, Multicenter, Randomized, Double-Masked, Sham-Controlled Clinical Trial for Leber's Hereditary Optic Neuropathy (LHON) Associated With ND4 Mutation

Inclusion Criteria: * Age at the time of signing the informed consent form: the age of the subjects must be ≥ 12 years old and ≤ 75 years old * The clinical manifestation of all subjects is reduced visual acuity caused by LHON associated with ND4 mutation, while the reduced visual acuity lasted for \> 6 months and \< 10 years * The clinical manifestation caused by LHON is vision loss, with a visual acuity of ≥ 0.5 LogMAR and ≤1.68 in BCVA in both eye The genotype test result is that there is G11778A mutation in ND4 gene, and there are no other primary LHON-associated mutations in the mitochondrial DNA (mtDNA) (ND1\[G3460A\] or ND6\[T14484C\]) (confirmed by a CLIA-certified international laboratory) Pupils can be adequately dilated for a comprehensive eye examination and visual acuity test Exclusion Criteria: * Any known allergy and/or hypersensitivity to the study drug or its constituents Contraindication to IVT injection in any eye * IVT drug delivery to any eye within 30 days prior to the screening visit History of vitrectomy in either eye * Narrow anterior chamber angle in any eye contra-indicating pupillary dilation * Presence of disorders or diseases of the eye or adnexa, excluding LHON, which may interfere with visual or ocular assessments, including optical coherence tomography during the study * Presence of known/documented mutations, other than the LHON-related mutation, which are known to cause pathology of the optic nerve, retina or afferent visual system * Pres…