Effect of Vagus Nerve Stimulation on Pain Intensity, Nerve Conduction Studies and Functional Outc… (NCT07405021) | Clinical Trial Compass
RecruitingNot Applicable
Effect of Vagus Nerve Stimulation on Pain Intensity, Nerve Conduction Studies and Functional Outcomes in Diabetic Peripheral Neuropathy Patients
Egypt40 participantsStarted 2026-01-01
Plain-language summary
To evaluate the efficacy of vagus nerve stimulation in reducing neuropathic pain, symptom severity, electrophysiological studies and functional outcomes in patients with diabetic peripheral neuropathy.
Who can participate
Age range
45 Years – 60 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria
* Thirty patients diagnosed with diabetic neuropathy of both genders.
* Age range between 45 and 60 years.
* Presence of numbness and/or pain in the feet with no other identifiable cause.
* Pain characterized as stabbing, electric shock-like, or burning in nature.
* Presence of glove-stocking sensory changes and abnormal sensations in the distal lower limbs.
* Ability to ambulate independently without assistance.
* Patients under full medical control.
* Hemoglobin A1c levels ranging from 6.5% to 7%.
* History of diabetes mellitus for more than 5 years.
Exclusion Criteria
* Implantation of cardiac pacemakers or other electrical stimulation devices.
* Presence of sinus bradycardia, sick sinus syndrome, or other cardiac arrhythmias.
* Lumbar radiculopathy.
* Psychiatric or mental disorders or history of seizures.
* Visual or auditory impairments or tremors affecting balance.
* Presence of other neuromuscular disorders.
* Foot deformities or active foot ulcers.
* History of lower limb surgical operations.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.