Effects of Ankle Block on Postoperative Analgesia in Diabetic and Non-Diabetic Patients (NCT07404124) | Clinical Trial Compass
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Effects of Ankle Block on Postoperative Analgesia in Diabetic and Non-Diabetic Patients
Turkey (Türkiye)46 participantsStarted 2026-03-01
Plain-language summary
This prospective observational study aims to evaluate the effects of ultrasound-guided ankle block on sensory and motor block characteristics and postoperative analgesic outcomes in patients undergoing lower extremity surgery. The study will compare diabetic and non-diabetic patients and will also assess the impact of glycemic control on block onset time and postoperative analgesic consumption.
Ankle block is commonly used in patients undergoing foot and ankle surgery, particularly in those with diabetes, peripheral neuropathy, or vascular disease, when general or neuraxial anesthesia may not be suitable. Previous studies suggest that diabetic neuropathy and impaired glycemic control may influence the onset and duration of peripheral nerve blocks.
Adult patients scheduled for lower extremity surgery under ankle block will be included. All procedures will be performed as part of routine clinical care, and no additional interventions will be applied for research purposes. Sensory and motor block onset times, postoperative pain scores, opioid consumption within the first 24 hours, and patient and surgeon satisfaction will be recorded.
The results of this study are expected to provide clinically relevant information regarding the effects of diabetes and glycemic control on ankle block characteristics and postoperative analgesia.
Who can participate
Age range
18 Years
Sex
ALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion Criteria:
* Adults aged 18 years and older.
* Patients scheduled for lower extremity surgery under ultrasound-guided ankle block as part of routine clinical care.
* Patients able to provide written informed consent.
* Availability of complete perioperative data including blood glucose levels, -HbA1c values, pain scores, and postoperative analgesic consumption.
Exclusion Criteria:
* Refusal or inability to provide informed consent.
* Failure of ankle block requiring conversion to another anesthesia technique.
* Known coagulation disorders contraindicating peripheral nerve block.
* Active infection at the site of block application.
* Chronic opioid or analgesic use, chronic alcohol use, or substance abuse.
* History of diabetic ketoacidosis or hyperosmolar hyperglycemic state.
* Severe renal or hepatic insufficiency.
* Known allergy to local anesthetics such as lidocaine or bupivacaine.
* Inability to perform perioperative blood glucose monitoring.
* Cognitive impairment or psychiatric conditions interfering with study participation or data collection.
Questions worth asking your doctor
Bring these to your next appointment. They're a starting point for a shared conversation — not a sign you qualify or a recommendation to enrol.
1Based on my diagnosis and history, is this trial worth exploring for me — or is there a standard treatment we should try first?
2What does this trial's phase tell us about how much is already known about its safety and benefit?
3What would taking part actually involve for me — visits, tests, time, and travel?
4What are the known and possible risks or side effects I should weigh, and how would they be monitored?
5If this trial isn't the right fit, what other options or trials would you suggest I look into?
Generated to help you prepare — always confirm anything about your own eligibility and care with the study team and your doctor.
Questions for the trial coordinator
The trial coordinator is the person who runs the study day to day. These cover the practical side — logistics, costs, and what taking part would actually mean for your life. The study team confirms whether you meet the criteria; these are questions to ask, not a sign you qualify.
1What does taking part actually involve week to week — how many visits, where, and how long does each one take?
2What costs are covered by the study, and what might I have to pay for myself, including travel, parking, or time off work?
3What happens during screening, and what happens if the study team confirms I don't meet the criteria after those tests?
4Who pays for the scans, blood work, and other tests the trial requires — the study, my insurance, or me?
5How will being in the trial affect my regular care, and will my own doctor stay informed and involved?
6Can I leave the trial at any point if I change my mind, and what would happen to my care if I do?
A starting point for the conversation — always confirm anything about your own eligibility, costs, and care with the study team and your doctor.
What they're measuring
1
Sensory Block Onset Time
Timeframe: From block completion up to 30 minutes after block administration
Trial details
NCT IDNCT07404124
SponsorFatih Sultan Mehmet Training and Research Hospital