A Study of Zasocitinib (TAK-279) in Adults With Active Crohn's Disease (NCT07403968) | Clinical Trial Compass
Not Yet RecruitingPhase 2
A Study of Zasocitinib (TAK-279) in Adults With Active Crohn's Disease
20 participantsStarted 2026-05-29
Plain-language summary
Crohn's disease (CD) is a serious, long-term condition that can cause swelling (inflammation) and painful ulcers anywhere in the gut. This study will investigate whether zasocitinib can improve CD biology at the cellular and molecular level in adults. The main aims of this study are to better understand zasocitinib's mechanism of action in CD and evaluate how safe this treatment is.
The participants will be treated with zasocitinib for 3 months (12 weeks) and will need to undergo a test where a doctor uses a thin, flexible tube with a tiny camera to look inside the large bowel (colon) and the end of the small bowel (ileum); this test is called ileocolonoscopy.
During the study, participants will visit the study clinic several times.
Who can participate
Age range18 Years – 75 Years
SexALL
See this in plain English?
AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.
Inclusion criteria
✓. Men and women aged 18 to 75 years can participate in the study.
✓. Must have been diagnosed with Crohn's disease (CD) at least 1 month (30 days) before study start.
✓. Must have received other treatments for CD earlier but no longer tolerate these treatments or the treatment no longer helps.
Exclusion criteria
✕. Cannot have another condition that causes swelling (inflammation) in the bowel.
✕. Cannot have complications of CD which may require surgery.
✕. Cannot have current abscesses or abscesses that have been treated within 6 weeks before study start.
✕. Cannot have had a removal of parts of the bowel within half a year (6 months) before study start.
✕. Cannot have had any surgery inside the belly (intraabdominal) within 3 months before study start.
✕. Cannot have or had a J-pouch.
What they're measuring
1
Number of Participants with Treatment-emergent Adverse Events (TEAEs) and Adverse Events of Special Interests (AESIs)
Timeframe: From start of study drug administration up to follow-up (up to Week 16)