The goal of this clinical trial is to evaluate the efficacy of a facial and neck cream containing Vitamin K2 in improving skin hydration, elasticity, firmness, and reducing wrinkles in 36 female participants aged 35-60 years with concerns of facial dryness, dullness, laxity, and neck lines. The main questions it aims to answer are: Does the test cream significantly improve skin hydration (Corneometer), reduce transepidermal water loss (Vapometer), and enhance skin elasticity and firmness (Cutometer) compared to a control cream? Does the test cream significantly reduce wrinkle severity (assessed by Rz and Ra parameters via AEVA-HE rapid optical imaging) in areas including the neck, cheeks, marionette lines, and crow's feet compared to a control cream? Researchers will compare the test cream (applied to one randomized half-face and neck) to the control cream (applied to the contralateral half-face and neck) to see if the test cream demonstrates superior efficacy in improving the measured skin parameters. Participants will: Apply the test cream to one assigned side of the face and neck, and the control cream to the other side, twice daily for 8 weeks. Attend evaluation visits at baseline, 2, 4, and 8 weeks for instrumental measurements (skin hydration, TEWL, elasticity, rapid optical imaging, facial imaging) and to complete subjective questionnaires.
Age range
35 Years – 60 Years
Sex
FEMALE
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Change in Facial Skin Elasticity (R0, R1 and F4)
Timeframe: At Baseline, Week 2, Week 4, and Week 8
Change in Roughness Parameters (Ra and Rz ) of Face and Neck Wrinkles
Timeframe: At Baseline, Week 2, Week 4, and Week 8
Change in Facial Sagging (Mandibular Plane Angle)
Timeframe: At Baseline, Week 2, Week 4, Week 8