The Effects of Preemptive Multimodal Analgesic on Endodontic Pain Following Root Canal Therapy. (NCT07400471) | Clinical Trial Compass
RecruitingEarly Phase 1
The Effects of Preemptive Multimodal Analgesic on Endodontic Pain Following Root Canal Therapy.
Bangladesh280 participantsStarted 2026-02-06
Plain-language summary
A clinical trial comparing preemptive multimodal analgesics with placebo in the management of immediate and chronic post-endodontic pain. The study utilizes statistical methods such as chi-squared, T-tests, and regression analysis, accounting for multiple outcomes with the Bonferroni adjustment. Duloxetine hydrochloride and pregabalin, both available in Bangladesh, are evaluated as experimental drugs, while placebos are used to assess psychological effects on pain. All participants receive standard interventional treatments, with acetaminophen provided as needed, and ethical considerations are addressed according to international guidelines.
Who can participate
Age range18 Years
SexALL
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Inclusion criteria
✓. Patient's aged 18 years more.
✓. ASA physical status I-II.
✓. Patient with the complain of pain originated from teeth and surrounding structure.
✓. Preoperative pain severity is moderate to severe.
✓. Patient can be able to make communication about their pain.
✓. Patients give consent to attain this research.
✓. Patients have others concomitant chronic pain.
✓. Patients who will have non-surgical endodontic treatment.
Exclusion criteria
✕. Patient would not like to attain in research.
✕. Patients have any medical condition those are contra indication for study drug.
✕. ASA physical status III, IV, V.
What they're measuring
1
Effects of Preemptive multimodal analgesia on post endodontic pain