Prospective, Non-interventional Study Assessing Perioral Rejuvenation Procedure
Austria34 participantsStarted 2026-02-13
Plain-language summary
The goal of this observational study is to learn how a perioral rejuvenation procedure affects perioral line severity and lip volume over time in adults undergoing routine aesthetic treatment in a single clinical center. The main questions it aims to answer are:
* What proportion of participants achieves a ≥1-point improvement from baseline on both the Lip Fullness Scale (LFS) and the Static Perioral Lines Assessment Scale (SPLAS) at Week 12?
* How do skin wrinkling/surface roughness, lip and perioral volume, and patient satisfaction change over 6 and 12 weeks?
Participants will:
* Receive a routine (non-study-mandated) holistic perioral rejuvenation procedure as decided by their treating clinician.
* Attend study visits at approximately baseline, Week 6, and Week 12.
* Undergo independent clinical assessments (assessor not involved in treatment delivery) of LFS and SPLAS.
* Have skin wrinkling and surface roughness documented by VISIA skin analysis (baseline, Week 6, Week 12).
* Have lip and perioral volume measured by VECTRA M3 volume analysis (baseline, Week 6, Week 12).
* Complete a standardized patient satisfaction questionnaire (Week 12).
Who can participate
Age range18 Years
SexALL
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Inclusion criteria
✓. 18 years or older at time of treatment.
✓. At least mild static perioral lines and maximum of thin lips, as assessed by the investigator.
✓. Participant has a stable medical condition with no uncontrolled systemic disease.
✓. Willingness to participate in the routine follow-up after 12 weeks and a signed ICF.
✓. Participant already visiting the clinic for the specific treatment.
Exclusion criteria
✕. Pregnancy and breast feeding.
✕. Known impairment of blood coagulation.
✕. Presence of acute infection or inflammation at the proposed injection sites.
✕. Hyaluronic Acid-Filler treatment in the perioral area within the last 6 months.
✕. Patients with a history of autoimmune disease or who are receiving immune therapy.
What they're measuring
1
Proportion of participants with a combined ≥ 1-point improvement in perioral line severity and lip fullness at Week 12