Comparison of IVF Outcomes Between PPOS and Antagonist Protocols in Women With PCOS (NCT07394530) | Clinical Trial Compass
RecruitingNot Applicable
Comparison of IVF Outcomes Between PPOS and Antagonist Protocols in Women With PCOS
Vietnam400 participantsStarted 2026-01-20
Plain-language summary
This study aims to compare the outcomes of two ovarian stimulation protocols used in in vitro fertilization (IVF): the progestin-primed ovarian stimulation (PPOS) protocol and the GnRH antagonist protocol.
Who can participate
Age range18 Years – 40 Years
SexFEMALE
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Inclusion Criteria:
* Women aged 18-40 years
* Diagnosed with polycystic ovary syndrome (PCOS) according to the modified Rotterdam criteria (2004) (≥2 of 3: oligo/anovulation, hyperandrogenism, or polycystic ovarian morphology on ultrasound)
* Indicated for in vitro fertilization (IVF) due to PCOS alone or PCOS with other infertility factors (e.g., tubal factor, previous failed IUI)
* Eligible for controlled ovarian stimulation for IVF
* Husband/partner with normal sperm parameters or mild to moderate oligoasthenoteratozoospermia (OAT)
* Willing and able to provide written informed consent and comply with study procedures.
Exclusion Criteria:
* Uterine abnormalities that may impair implantation or pregnancy outcomes, including congenital uterine malformations, large fibroids distorting the uterine cavity, adenomyosis, or severe intrauterine pathology.
* History of major ovarian or uterine surgery affecting ovarian reserve or uterine structure (e.g., ovarian cystectomy, endometriosis surgery, myomectomy, unilateral oophorectomy)
* History of recurrent pregnancy loss (≥3 spontaneous miscarriages)
* Known chromosomal abnormalities in either partner
* Inability to adhere to study protocol or follow-up procedures