By InvitationPhase 4

Musculoskeletal Outcomes Using Tylenol/Ibuprofen vs. Oral Steroids in New Injuries

United States60 participantsStarted 2025-09-17

Plain-language summary

In this pilot study, the investigators aim to compare two short-term pain relief methods administered over the course of 6 days in the setting of acute musculoskeletal (MSK) pain: 1. Methylprednisolone((Medrol)dose pack- standard taper per dose pack instructions 2. Standard of Care (SOC) which includes a combination of Acetaminophen (Tylenol)+Ibuprofen (Motrin) The investigators are interested in studying pain relief regimens for acute injury of any body part among an adult orthopaedic urgent care population.

Who can participate

Age range18 Years

SexALL

See this in plain English?

AI-rewrites the medical criteria so a patient or caregiver can understand them. Always confirm with the trial site.

Inclusion Criteria: * Adults 18+ * Able to answer survey questions in English * MSK pain \> 3 on the VAS scale in any body part * Invited to participate by and enrolling clinician Exclusion Criteria: * \> 2 weeks from pain onset * Fractures * Active infections * Anaphylactic reaction to either medication (Oral Steroids, Ibuprofen, and/or Acetaminophen) * Currently taking anti-platelet agents (aspirin \</= 100/mg a day, clopidogrel, etc.) * Chronic Kidney Disease Stage 3 or worse * Uncontrolled diabetes (A1C above 9) * Currently taking oral anti-coagulants * History of bleeding ulcer * Cirrhosis * Taking daily prednisone * Chronic pain syndrome * Chronic pain medication (gabapentin, Lyrica, narcotics, etc.) * Pregnant Patients * Worker's Compensation Patients

What they're measuring

Change in Pain

Timeframe: 1 week, 1 month

Trial details

NCT IDNCT07393503

SponsorState University of New York at Buffalo

Sponsor typeOTHER

Study typeINTERVENTIONAL

Primary completion2026-08

View on ClinicalTrials.gov More Musculoskeletal Pain trials