Switch From 2mg Aflibercept to 8mg Aflibercept in Patients With Neovascular Age-related Macular D… (NCT07390253) | Clinical Trial Compass
Active — Not RecruitingNot Applicable
Switch From 2mg Aflibercept to 8mg Aflibercept in Patients With Neovascular Age-related Macular Degeneration
Austria50 participantsStarted 2024-09-18
Plain-language summary
This study will investigate if switching patients who appear to be sub-optimal responders to the current standard of care treatment with Aflibercept 2mg to Aflibercept 8mg will prolong treatment intervals and maintain visual acuity.
Who can participate
Age range21 Years – 105 Years
SexALL
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Inclusion Criteria:
* Patients, who received prior intravitreal anti-VEGF-treatment for nAMD with Aflibercept 2mg. A minimum of four injections of Aflibercept 2mg is required. Therefore 16-24 weeks prior treatment with anti-VEGF is required in line with an interval of 4-8 weeks.
* Short treatment intervals of 4 or 8 weeks
* nAMD
* Age 21 or older
* Written informed consent
Exclusion Criteria:
* Chronic treatment with Bevacizumab or Faricimab
* Extensive macular fibrosis
* Diabetic retinopathy
* Other retinal pathologies (e.g. retinal vein occlusion)
* Dense media opacities (cataract, corneal scars)
* Vitreous hemorrhage
* Ocular or periocular infections
* Active intraocular inflammation
* Hypersensitivity to the active substance or to any of the excipients
* Prior Aflibercept 8mg treatment
* Pregnancy (for women in reproductive age a pregnancy test will be performed)
What they're measuring
1
Number of intravitreal injections
Timeframe: 12 months
Trial details
NCT IDNCT07390253
SponsorVienna Institute for Research in Ocular Surgery